Trevox 500mg Tablet

✔️ Uses of Trevox 500

• Urinary Tract infections
• Skin and soft tissue infections
• Respiratory tract infections
• Inhalation Anthrax
• Plague

✔️ How does Trevox 500 work?

Trevox 500mg tablet works by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them.

✔️ Side Effects of Trevox 500

• Diarrhea
• Stomach pain
• Confusion
• Fever
• Skin rash
• Change in taste
• Constipation
• Dizziness
• Headache
• Nausea or vomiting

✔️ Quick Suggestions:

• Follow the prescribed dosage and complete the full course of treatment, even if you start feeling better. Skipping doses or stopping early can lead to incomplete treatment and the risk of recurring or resistant infections.
• If you experience a rash, itchy skin, swelling of the face and mouth, or difficulty breathing, discontinue the medication immediately and inform your doctor. These may be signs of an allergic reaction and require immediate medical attention.
• Diarrhea is a possible side effect of levofloxacin, but it should generally stop once the course is complete. However, if the diarrhea persists or if you notice blood in your stools, inform your doctor.
• Notify your doctor if you experience pain in your tendons, or if you have numbness or tingling sensations. These symptoms may indicate tendonitis or nerve damage, which can occur rarely with levofloxacin use.
• Inform your doctor if you are pregnant, planning to conceive, or breastfeeding. Levofloxacin is generally not recommended during pregnancy or while breastfeeding. Avoid dairy products such as milk and yogurt for at least 2 hours before and after taking the medication, as they can interfere with its absorption.
• Practice good hygiene to prevent the spread of infection and maintain overall health.
• Including fiber-rich foods in your diet can help promote the growth of healthy gut bacteria, which may have been affected by the antibiotic treatment. This can help restore a healthy balance in your gut.
• After completing the full course of levofloxacin, it is advisable to take probiotics to help replenish and restore healthy bacteria in the intestines. This can help minimize the risk of antibiotic-associated diarrhea.

Special Advice:

• Limit exposure to heavy sunlight or artificial UV rays (e.g., tanning beds) during treatment with levofloxacin and for 48 hours after discontinuation. Levofloxacin can make your skin more sensitive to sunlight, increasing the risk of sunburn or skin reactions.
• If you are using levofloxacin eye drops, remove contact lenses before applying the drops and wait at least 15 minutes before reinserting them.
• Depending on your medical condition, your doctor may monitor your liver function, kidney function, white blood cell count, and blood glucose levels during treatment with levofloxacin, especially if you have pre-existing liver or kidney problems or if you are diabetic. This helps ensure the medication is well-tolerated and does not cause any harmful interactions.

✔️ Indication of Trevox 500mg Tablet

Trevox 500mg Tablet is indicated for the treatment of various infections, including:

• Acute sinusitis: It helps in treating infections in the sinus cavities, relieving symptoms such as nasal congestion, facial pain, and headache.
• Lung infections: Trevox 500mg Tablet is effective in treating lung infections, including pneumonia and chronic bronchitis. It helps in alleviating breathing difficulties and other respiratory symptoms.
• Urinary tract infections: It is used to treat infections in the urinary tract, including the kidneys and bladder. Symptoms such as frequent urination, burning sensation, and pain are relieved with its use.
• Prostate gland infections: Trevox 500mg Tablet can be used to treat infections in the prostate gland, relieving symptoms such as pain in the pelvic region, difficulty urinating, and urinary urgency.
• Skin and soft tissue infections: It is effective in treating infections in the skin and soft tissues, including muscles. It helps in reducing inflammation, pain, and swelling associated with these infections.
• In addition to treating these infections, Trevox 500mg Tablet is also prescribed to reduce the risk of developing anthrax or prevent the worsening of the disease after exposure to anthrax-causing bacteria. Anthrax is a serious pulmonary disease that can be life-threatening.

It is important to note that Trevox 500mg Tablet should only be used under the guidance and prescription of a healthcare professional. The dosage and duration of treatment will be determined by the severity of the infection and individual patient factors.

✔️ Pharmacology

Levofloxacin is indeed a third-generation fluoroquinolone antibiotic with broad-spectrum activity against various bacteria. It is a synthetic compound characterized by a chiral fluorinated carboxy quinolone structure. The mechanism of action of levofloxacin involves the inhibition of bacterial enzymes essential for DNA replication, transcription repair, and recombination, namely topoisomerase IV and DNA gyrase.

By targeting these enzymes, levofloxacin disrupts the normal functioning of bacterial DNA, leading to the inhibition of bacterial growth and eventual bacterial cell death. It exhibits antimicrobial activity against a wide range of gram-negative bacteria in vitro.

It is worth noting that the effectiveness of levofloxacin against specific bacteria may vary, and its use should be based on the susceptibility of the target pathogen as determined by appropriate testing.

✔️ Dosage & Administration of Trevox 500mg Tablet

Dosages of levofloxacin for various indications in adults and children are as follows:

Adults:

1. Acute sinusitis: 500 mg once daily for 10-14 days, or 750 mg once daily for 5 days.
2. Exacerbation of chronic bronchitis (uncomplicated): 500 mg once daily for 7 days, or 750 mg once daily for 3 days.
3. Exacerbation of chronic bronchitis (complicated): 750 mg once daily for 5 days.
4. Community-acquired pneumonia: 500 mg once daily for 7-14 days, or 750 mg once daily for 5 days.
5. Uncomplicated urinary-tract infections: 250 mg once daily for 3 days.
6. Complicated urinary tract infections and acute pyelonephritis: 250 mg once daily for 7-10 days.
7. Uncomplicated skin and soft-tissue infections: 500 mg once daily for 7-10 days.
8. Complicated skin and soft-tissue infections: 750 mg once daily for 7-14 days.
9. Enteric fever: 500 mg once daily for 7-14 days.
10. Diarrhea, cholera, shigellosis & enteritis:

• Mild to moderate case: 500 mg (single dose).
• Moderate to severe case: 500 mg once daily for 3 days.

Children:

1. Children 6 months to <5 years: 10 mg/kg every 12 hours.
2. Children >5 years: 10 mg/kg every 24 hours.

The dosing of levofloxacin in patients with renal impairment is as follows:

For patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD):

• Initially, 500 mg daily, then 250 mg every 48 hours.
• Alternatively, initially, 750 mg daily, then 500 mg every 48 hours.

For patients with a creatinine clearance (CrCl) of 20-49 ml/min:

• Initially, 500 mg daily, then 250 mg every 24 hours.
• Alternatively, initially, 750 mg daily, then 750 mg every 48 hours.

For patients with a CrCl of 10-19 ml/min:

• Initially, 500 mg daily, then 250 mg every 48 hours.
• Alternatively, initially, 750 mg daily, then 500 mg every 48 hours.

It's important to note that dosage adjustments in renal impairment should be done based on the patient's creatinine clearance and under the guidance of a healthcare professional. Close monitoring of renal function and adjustment of dosage may be necessary to ensure appropriate treatment and prevent potential side effects.

✔️ Interaction

Levofloxacin may interact with several medications, and it is important to consult with a doctor before taking Trevox 500mg Tablet, especially if you are taking any of the following medications:

• Pain-relieving drugs (NSAIDs): Concurrent use of NSAIDs with levofloxacin may increase the risk of developing central nervous system stimulation and seizures.
• Acidity relievers (cimetidine): Cimetidine may interfere with the elimination of levofloxacin from the body, leading to increased levels of levofloxacin.
• Anti-tuberculosis drugs (probenecid): Probenecid may delay the elimination of levofloxacin from the body, leading to increased levels of levofloxacin.
• Immunosuppressants (cyclosporine): Concurrent use of levofloxacin with cyclosporine may increase the risk of toxicity associated with cyclosporine.
• Anti-bacterial drugs (macrolides): Co-administration of levofloxacin with macrolide antibiotics may increase the risk of QT prolongation and irregular heart rhythms.
• Blood sugar-lowering drugs (insulin, glibenclamide): Levofloxacin may enhance the effects of blood sugar-lowering drugs, leading to hypoglycemia (low blood sugar levels).
• Blood thinners (warfarin): Levofloxacin may increase the effects of blood thinners, leading to an increased risk of bleeding.
• Fits medications (phenytoin, valproate): Levofloxacin may decrease the effectiveness of fits medications, and the levels of phenytoin or valproate in the blood may need to be monitored.
• Additionally, it is recommended to avoid taking Trevox 500mg Tablet with milk and yogurt, as they may interfere with the absorption of levofloxacin.

Trevox 500mg Tablet should be taken only after a doctor's consultation for conditions such as swollen intestines (colitis), weak muscles (myasthenia gravis), swollen tendons (tendonitis), high blood sugar (diabetes), hemodialysis (kidney dialysis), kidney dysfunction, and diseases of nerves. The doctor will assess the risks and benefits and provide appropriate guidance for the use of Trevox 500mg Tablet in these conditions.

✔️ Contraindications

Patients with a history of hypersensitivity to levofloxacin, quinolone antimicrobial agents, or any other component of this product should not take it.

✔️ Pregnancy & Lactation

Levofloxacin is generally not recommended for use during pregnancy or while nursing due to limited information on its effects on the unborn child or nursing infant. Studies in animals have shown potential harm to the fetus, and there is a risk of adverse effects on the development of joints in pediatric patients. Additionally, levofloxacin can pass into breast milk and may cause harm to the nursing infant. It is important to consult with a healthcare professional to discuss the potential risks and benefits before using levofloxacin during pregnancy or while breastfeeding. Alternative treatment options may be considered to ensure the safety of both the mother and the baby.

✔️ Precautions & Warnings

It is important to note the following precautions and warnings when taking Trevox 500mg Tablet:

• Allergy: Do not take Trevox 500mg Tablet if you are allergic to levofloxacin or any other fluoroquinolone antibiotics, such as delafloxacin, gemifloxacin, ofloxacin, moxifloxacin, and ciprofloxacin. Serious allergic reactions can occur.
• Tendinitis and Tendon Rupture: Trevox 500mg Tablet may increase the risk of developing tendinitis (inflammation of a tendon) or experiencing a tendon rupture (tearing of a tendon). This risk is higher in older adults, those taking corticosteroids, and those with kidney, heart, or lung transplants. If you experience pain, inflammation, or rupture of a tendon, discontinue the medication and seek medical attention immediately.
• Kidney Disease: Inform your doctor if you have a history of kidney disease, as dosage adjustments may be required to prevent potential complications.
• Joint or Tendon Disorders: Individuals with pre-existing joint or tendon disorders, such as rheumatoid arthritis, may be at an increased risk of developing tendon-related complications while taking Trevox 500mg Tablet. Exercise caution and inform your doctor about your condition.
• Seizures and Epilepsy: Trevox 500mg Tablet may lower the seizure threshold and increase the risk of seizures in individuals with a history of seizures or epilepsy. Use with caution and inform your doctor if you have these conditions.
• Myasthenia Gravis: Trevox 500mg Tablet can worsen muscle weakness in individuals with myasthenia gravis, a neuromuscular disorder. Report any increased weakness to your doctor.
• Dairy Products and Sunlight: Avoid consuming dairy products close to the time of taking the Trevox 500mg Tablet, as they can interfere with the absorption of the medication. Additionally, exposure to sunlight or artificial UV rays should be minimized, as Trevox 500mg Tablet can increase the risk of phototoxicity or photosensitivity reactions.
• Epilepsy and Irregular Heartbeat: Patients with epilepsy or a history of irregular heartbeat (QT prolongation) should inform their doctor before taking Trevox 500mg Tablet, as the medication may have potential effects on these conditions.

✔️ Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.